Conceptual design of three-dimensional scaffolds of powder-based materials for bone tissue engineering applications

Vasireddi, Ramakrishna and Basu, Bikramjit (2015) Conceptual design of three-dimensional scaffolds of powder-based materials for bone tissue engineering applications. In: RAPID PROTOTYPING JOURNAL, 21 (6). pp. 716-724.

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Abstract

Purpose - The purpose of this paper is to investigate the possibility to construct tissue-engineered bone repair scaffolds with pore size distributions using rapid prototyping techniques. Design/methodology/approach - The fabrication of porous scaffolds with complex porous architectures represents a major challenge in tissue engineering and the design aspects to mimic complex pore shape as well as spatial distribution of pore sizes of natural hard tissue remain unexplored. In this context, this work aims to evaluate the three-dimensional printing process to study its potential for scaffold fabrication as well as some innovative design of homogeneously porous or gradient porous scaffolds is described and such design has wider implication in the field of bone tissue engineering. Findings - The present work discusses biomedically relevant various design strategies with spatial/radial gradient in pore sizes as well as with different pore sizes and with different pore geometries. Originality/value - One of the important implications of the proposed novel design scheme would be the development of porous bioactive/biodegradable composites with gradient pore size, porosity, composition and with spatially distributed biochemical stimuli so that stem cells loaded into scaffolds would develop into complex tissues such as those at the bone-cartilage interface.

Item Type:	Journal Article
Publication:	RAPID PROTOTYPING JOURNAL
Publisher:	EMERALD GROUP PUBLISHING LTD
Additional Information:	Copy right for this article belongs to the EMERALD GROUP PUBLISHING LTD, HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND
Keywords:	Design; Bones; Computer-aided design; 3D; Porous materials; Prototyping
Department/Centre:	Division of Chemical Sciences > Materials Research Centre
Date Deposited:	04 Mar 2016 06:01
Last Modified:	04 Mar 2016 06:01
URI:	http://eprints.iisc.ac.in/id/eprint/53384

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