Transition metal-free Minisci reaction promoted by NCS, and TBHP: acylation of heteroarenes

Siddaraju, Yogesh and Prabhu, Kandikere Ramaiah (2016) Transition metal-free Minisci reaction promoted by NCS, and TBHP: acylation of heteroarenes. In: TETRAHEDRON, 72 (7). pp. 959-967.

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Abstract

A method for acylation for heteroarenes under metal-free conditions has been described using NCS as an additive and TBHP as an oxidant. This method has been successfully employed in acylation of a variety of aldehyde with heteroarenes. The application of the method has been illustrated in synthesizing isoquinoline derived natural products. This strategy provides an efficient, mild and inexpensive method for acylation of heteroarenes. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Publication:	TETRAHEDRON
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Additional Information:	Copy right for this article belongs to the PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Keywords:	Isoquinoline; Minisci reaction; C-H functionalization; Acylation; Metal-free reactions
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	04 Mar 2016 07:16
Last Modified:	04 Mar 2016 07:16
URI:	http://eprints.iisc.ac.in/id/eprint/53351

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