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Iron(III) salicylates of dipicolylamine bases showing photo-induced anticancer activity and cytosolic localization

Garai, Aditya and Pant, Ila and Kondaiah, Paturu and Chakravarty, Akhil R (2015) Iron(III) salicylates of dipicolylamine bases showing photo-induced anticancer activity and cytosolic localization. In: POLYHEDRON, 102 . pp. 668-676.

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Official URL: http://dx.doi.org/10.1016/j.poly.2015.10.026


An iron(III) salicylate having a dipicolylamine base (andpa) with a photoactive anthracenyl moiety is prepared, characterized, and studied for its photo-induced anticancer activity and cellular localization in HeLa and MCF-7 cells. Its phenyl analogue is structurally characterized by X-ray crystallography. The complex has a ternary structure in which the dipicolylamine ligand and salicylic acid in dianionic form (sal) display respective tridentate and bidentate mode of coordination in Fe(sal)(phdpa)Cl] (1). Complex Fe(sal)(andpa)Cl] (2) having a pendant anthracenyl moiety shows significant photocytotoxicity in visible light (400-700 nm) giving IC50 values of 8.6 +/- 0.7 and 3.4 +/- 0.9 mu M in HeLa and MCF-7 cells, while being essentially nontoxic in the dark (IC50 > 100 mu M). The complex shows cytosolic localization in the cancer cells. Formation of hydroxyl radicals ((OH)-O-center dot) as the reactive oxygen species is evidenced from the pUC19 DNA photocleavage studies. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Publication: POLYHEDRON
Additional Information: Copy right for this article belongs to the PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Keywords: Iron; Salicylic acid; Crystal structure; Photocytotoxicity; Cellular imaging
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 17 Feb 2016 05:35
Last Modified: 17 Feb 2016 05:35
URI: http://eprints.iisc.ac.in/id/eprint/53248

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