Nahar, Smita and Bose, Debojit and Pal, Sudip and Chakraborty, Tushar Kanti and Maiti, Souvik (2015) Cyclic Cationic Peptides Containing Sugar Amino Acids Selectively Distinguishes and Inhibits Maturation of Pre-miRNAs of the Same Family. In: NUCLEIC ACID THERAPEUTICS, 25 (6). pp. 323-329.
Full text not available from this repository. (Request a copy)Abstract
The discovery of microRNAs (miRNAs) has added a new dimension to the gene regulatory networks, making aberrantly expressed miRNAs as therapeutically important targets. Small molecules that can selectively target and modulate miRNA levels can thus serve as lead structures. Cationic cyclic peptides containing sugar amino acids represent a new class of small molecules that can target miRNA selectively. Upon treatment of these small molecules in breast cancer cell line, we profiled 96 therapeutically important miRNAs associated with cancer and observed that these peptides can selectively target paralogous miRNAs of the same seed family. This selective inhibition is of prime significance in cases when miRNAs of the same family have tissue-specific expression and perform different functions. During these conditions, targeting an entire miRNA family could lead to undesired adverse effects. The selective targeting is attributable to the difference in the three-dimensional structures of precursor miRNAs. Hence, the core structure of these peptides can be used as a scaffold for designing more potent inhibitors of miRNA maturation and hence function.
| Item Type: | Journal Article |
|---|---|
| Publication: | NUCLEIC ACID THERAPEUTICS |
| Publisher: | MARY ANN LIEBERT, INC |
| Additional Information: | Copy right for this article belongs to the MARY ANN LIEBERT, INC, 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 02 Jan 2016 07:31 |
| Last Modified: | 02 Jan 2016 07:31 |
| URI: | http://eprints.iisc.ac.in/id/eprint/52997 |
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