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A novel gene THSD7A is associated with obesity

Nizamuddin, S and Govindaraj, P and Saxena, S and Kashyap, M and Mishra, A and Singh, S and Rotti, H and Raval, R and Nayak, J and Bhat, BK and Prasanna, BV and Dhumal, VR and Bhale, S and Joshi, KS and Dedge, AP and Bharadwaj, R and Gangadharan, GG and Nair, S and Gopinath, PM and Patwardhan, B and Kondaiah, P and Satyamoorthy, K and Valiathan, MS and Thangaraj, K (2015) A novel gene THSD7A is associated with obesity. In: INTERNATIONAL JOURNAL OF OBESITY, 39 (11). pp. 1662-1665.

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Official URL: http://dx.doi.org/10.1038/ijo.2015.144


Body mass index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian populations are admixture of two ancestral populations; ancestral north Indians (ANI) and ancestral south Indians (ASI). Although ANI are related to Europeans, ASI are not related to any group outside Indian-subcontinent. Hence, we expect novel genetic loci associated with BMI. In association analysis, we found eight genic SNPs in extreme of distribution (P <= 3.75 x 10(-5)), of which WWOX has already been reported to be associated with obesity-related traits hence excluded from further study. Interestingly, we observed rs1526538, an intronic SNP of THSD7A; a novel gene significantly associated with obesity (P = 2.88 x 10(-5), 8.922 x 10(-6) and 2.504 x 10(-9) in discovery, replication and combined stages, respectively). THSD7A is neural N-glycoprotein, which promotes angiogenesis and it is well known that angiogenesis modulates obesity, adipose metabolism and insulin sensitivity, hence our result find a correlation. This information can be used for drug target, early diagnosis of obesity and treatment.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 15 Dec 2015 07:47
Last Modified: 15 Dec 2015 07:47
URI: http://eprints.iisc.ac.in/id/eprint/52915

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