Kumar, Rajesh and Shukla, Shashi Kant and Pandey, Anand and Srivastava, Sanjeev Kumar and Dikshit, Anupam (2015) Copper oxide nanoparticles: an antidermatophytic agent for Trichophyton spp. In: Nanotechnology Reviews, 4 (5, SI). pp. 401-409.
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Copper oxide (CuO) is one of the most important transition metal oxides due to its unique properties. It is used in various technological applications such as high critical temperature, superconductors, gas sensors, in photoconductive applications and so on. Recently, it has been used as an antimicrobial agent against various pathogenic bacteria. In the present investigation, we studied the structural and antidermatophytic properties of CuO nanoparticles (NPs) synthesized by a precipitation technique. Copper sulfate was used as a precursor and sodium hydroxide as a reducing agent. Scanning electron microscopy (SEM) showed flower-shaped CuO NPs and X-ray diffraction (XRD) pattern showed the crystalline nature of CuO NPs. These NPs were evaluated against two prevalent species of dermatophytes, i.e. Trichophyton rubrum and T. mentagrophytes by using the broth microdilution technique. Further, the NPs activity was also compared with synthetic sertaconazole. Although better antidermatophytic activity was exhibited with sertaconazole as compared to NPs, being synthetic, sertaconazole may not be preferred, as it shows different adverse effects. Trichophyton mentagrophytes is more susceptible to NPs than T. rubrum. A phylogenetic approach was applied for predicting differences in susceptibility of pathogens.
| Item Type: | Journal Article |
|---|---|
| Publication: | Nanotechnology Reviews |
| Publisher: | WALTER DE GRUYTER GMBH |
| Additional Information: | Copy right for this article belongs to the WALTER DE GRUYTER GMBH, GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY |
| Keywords: | antimicrobial agent; broth microdilution method; SEM; Trichophyton; XRD |
| Department/Centre: | Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering |
| Date Deposited: | 10 Dec 2015 06:09 |
| Last Modified: | 10 Dec 2015 06:09 |
| URI: | http://eprints.iisc.ac.in/id/eprint/52887 |
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