Genome-wide analysis correlates Ayurveda Prakriti

Govindaraj, Periyasamy and Nizamuddin, Sheikh and Sharath, Anugula and Jyothi, Vuskamalla and Rotti, Harish and Raval, Ritu and Nayak, Jayakrishna and Bhat, Balakrishna K and Prasanna, BV and Shintre, Pooja and Sule, Mayura and Joshi, Kalpana S and Dedge, Amrish P and Bharadwaj, Ramachandra and Gangadharan, GG and Nair, Sreekumaran and Gopinath, Puthiya M and Patwardhan, Bhushan and Kondaiah, Paturu and Satyamoorthy, Kapaettu and Valiathan, Marthanda Varma Sankaran and Thangaraj, Kumarasamy (2015) Genome-wide analysis correlates Ayurveda Prakriti. In: SCIENTIFIC REPORTS, 5 .

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Abstract

The practice of Ayurveda, the traditional medicine of India, is based on the concept of three major constitutional types (Vata, Pitta and Kapha) defined as ``Prakriti''. To the best of our knowledge, no study has convincingly correlated genomic variations with the classification of Prakriti. In the present study, we performed genome-wide SNP (single nucleotide polymorphism) analysis (Affymetrix, 6.0) of 262 well-classified male individuals (after screening 3416 subjects) belonging to three Prakritis. We found 52 SNPs (p <= 1 x 10(-5)) were significantly different between Prakritis, without any confounding effect of stratification, after 10(6) permutations. Principal component analysis (PCA) of these SNPs classified 262 individuals into their respective groups (Vata, Pitta and Kapha) irrespective of their ancestry, which represent its power in categorization. We further validated our finding with 297 Indian population samples with known ancestry. Subsequently, we found that PGM1 correlates with phenotype of Pitta as described in the ancient text of Caraka Samhita, suggesting that the phenotypic classification of India's traditional medicine has a genetic basis; and its Prakriti-based practice in vogue for many centuries resonates with personalized medicine.

Item Type:	Journal Article
Publication:	SCIENTIFIC REPORTS
Publisher:	NATURE PUBLISHING GROUP
Additional Information:	Copy right for this article belongs to the NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	19 Nov 2015 04:50
Last Modified:	19 Nov 2015 04:50
URI:	http://eprints.iisc.ac.in/id/eprint/52760

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