Scaling law characterizing the dynamics of the transition of HIV-1 to error catastrophe

Gupta, Vipul and Dixit, Narendra M (2015) Scaling law characterizing the dynamics of the transition of HIV-1 to error catastrophe. In: PHYSICAL BIOLOGY, 12 (5).

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Abstract

Increasing the mutation rate, mu, of viruses above a threshold, mu(c), has been predicted to trigger a catastrophic loss of viral genetic information and is being explored as a novel intervention strategy. Here, we examine the dynamics of this transition using stochastic simulations mimicking within-host HIV-1 evolution. We find a scaling law governing the characteristic time of the transition: tau approximate to 0.6/(mu - mu(c)). The law is robust to variations in underlying evolutionary forces and presents guidelines for treatment of HIV-1 infection with mutagens. We estimate that many years of treatment would be required before HIV-1 can suffer an error catastrophe.

Item Type:	Journal Article
Publication:	PHYSICAL BIOLOGY
Publisher:	IOP PUBLISHING LTD
Additional Information:	Copy right for this article belongs to the IOP PUBLISHING LTD, TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
Keywords:	error catastrophe; quasispecies; HIV; mutagen; scaling law
Department/Centre:	Division of Mechanical Sciences > Chemical Engineering
Date Deposited:	30 Oct 2015 07:03
Last Modified:	30 Oct 2015 07:03
URI:	http://eprints.iisc.ac.in/id/eprint/52639

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