Exploring the potential of adjunct therapy in tuberculosis

Rayasaml, Geetha Vani and Balganesh, Tanjore S (2015) Exploring the potential of adjunct therapy in tuberculosis. In: TRENDS IN PHARMACOLOGICAL SCIENCES, 36 (8). pp. 506-513.

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Abstract

A critical unmet need for treatment of drug-resistant tuberculosis (TB) is to find novel therapies that are efficacious, safe, and shorten the duration of treatment. Drug discovery approaches for TB primarily target essential genes of the pathogen Mycobacterium tuberculosis (Mtb) but novel strategies such as host-directed therapies and nonmicrobicidal targets are necessary to bring about a paradigm shift in treatment. Drugs targeting the host pathways and nonmicrobicidal proteins can be used only in conjunction with existing drugs as adjunct therapies. Significantly, host-directed adjunct therapies have the potential to decrease duration of treatment, as they are less prone to drug resistance, target the immune responses, and act via novel mechanism of action. Recent advances in targeting host-pathogen interactions have implicated pathways such as eicosanoid regulation and angiogenesis. Furthermore, several approved drugs such as metformin and verapamil have been identified that appear suitable for repurposing for the treatment of TB. These findings and the challenges in the area of host- and/or pathogen-directed adjunct therapies and their implications for TB therapy are discussed.

Item Type:	Journal Article
Publication:	TRENDS IN PHARMACOLOGICAL SCIENCES
Publisher:	ELSEVIER SCIENCE LONDON
Additional Information:	Copy right for this article belongs to the ELSEVIER SCIENCE LONDON, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
Keywords:	host-directed adjunct therapies; repurposed drugs; efflux pump; virulence factors
Department/Centre:	Others
Date Deposited:	24 Sep 2015 06:28
Last Modified:	24 Sep 2015 06:28
URI:	http://eprints.iisc.ac.in/id/eprint/52406

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