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Photoacoustic tomography of the human finger: towards the assessment of inflammatory joint diseases

van Es, P and Biswas, SK and Moens, Bernlot HJ and Steenbergen, W and Manohar, S (2015) Photoacoustic tomography of the human finger: towards the assessment of inflammatory joint diseases. In: PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2015, FEB 08-10, 2015, San Francisco, CA.

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Official URL: http://dx.doi.org/ 10.1117/12.2078676


Inflammatory arthritis is often manifested in finger joints. The growth of new or withdrawal of old blood vessels can be a sensitive marker for these diseases. Photoacoustic (PA) imaging has great potential in this respect since it allows the sensitive and highly resolved visualization of blood. We systematically investigated PA imaging of finger vasculature in healthy volunteers using a newly developed PA tomographic system. We present the PA results which show excellent detail of the vasculature. Vessels with diameters ranging between 100 mu m and 1.5 mm are visible along with details of the skin, including the epidermis and the subpapillary plexus. The focus of all the studies is at the proximal and distal interphalangeal joints, and in the context of ultimately visualizing the inflamed synovial membrane in patients. This work is important in laying the foundation for detailed research into PA imaging of the phalangeal vasculature in patients suffering from rheumatoid arthritis.

Item Type: Conference Proceedings
Series.: Proceedings of SPIE
Additional Information: Copy right for this article belongs to the SPIE-INT SOC OPTICAL ENGINEERING, 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
Keywords: photoacoustic computed tomography; rheumatoid arthritis; vasculature; finger
Department/Centre: Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics
Date Deposited: 22 Jun 2015 07:05
Last Modified: 22 Jun 2015 07:05
URI: http://eprints.iisc.ac.in/id/eprint/51744

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