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Copolyesters from Soybean Oil for Use as Resorbable Biomaterials

Kolanthai, Elayaraja and Sarkar, Kishor and Meka, Sai Rama Krishna and Madras, Giridhar and Chatterjee, Kaushik (2015) Copolyesters from Soybean Oil for Use as Resorbable Biomaterials. In: ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 3 (5). pp. 880-891.

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Official URL: http://dx.doi.org/ 10.1021/acssuschemeng.5b00001


A family of soybean oil (SO) based biodegradable cross-linked copolyesters sourced from renewable resources was developed for use as resorbable biomaterials. The polyesters were prepared by a melt condensation of epoxidized soybean oil polyol and sebacic acid with citric acid (CA) as a cross-linker. D-Mannitol (M) was added as an additional reactant to improve mechanical properties. Differential scanning calorimetry revealed that the polyester synthesized using only CA as the cross-linker was semicrystalline and elastomeric at physiological temperature. The polymers were hydrophobic in nature. The water wettability, elongation at break and the degradation rate of the polyesters decreased with increase in M content or curing time. Modeling of release kinetics of dyes showed a diffusion controlled mechanism underlies the observed sustained release from these polymers. The polyesters supported attachment and proliferation of human stem cells and were thus cytocompatible. Porous scaffolds induced osteogenic differentiation of the stern cells suggesting that these polymers are well suited for bone tissue engineering. Thus, this family of polyesters offers a low cost and green alternative as biocompatible, bioresobable polymers for potential use as resorbable biomaterials for tissue engineering and controlled release.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Keywords: Polyester; Elastomer; Renewable resources; Tissue scaffold; Controlled release
Department/Centre: Division of Mechanical Sciences > Chemical Engineering
Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 22 Jun 2015 05:35
Last Modified: 22 Jun 2015 05:35
URI: http://eprints.iisc.ac.in/id/eprint/51728

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