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Key challenges for the creation and maintenance of specialist protein resources

Holliday, Gemma L and Bairoch, Amos and Bagos, Pantelis G and Chatonnet, Arnaud and Craik, David J and Finn, Robert D and Henrissat, Bernard and Landsman, David and Manning, Gerard and Nagano, Nozomi and O'Donovan, Claire and Pruitt, Kim D and Rawlings, Neil D and Saier, Milton and Sowdhamini, Ramanathan and Spedding, Michael and Srinivasan, Narayanaswamy and Vriend, Gert and Babbitt, Patricia C and Bateman, Alex (2015) Key challenges for the creation and maintenance of specialist protein resources. In: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 83 (6). pp. 1005-1013.

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Official URL: http://dx.doi.org/ 10.1002/prot.24803


As the volume of data relating to proteins increases, researchers rely more and more on the analysis of published data, thus increasing the importance of good access to these data that vary from the supplemental material of individual articles, all the way to major reference databases with professional staff and long-term funding. Specialist protein resources fill an important middle ground, providing interactive web interfaces to their databases for a focused topic or family of proteins, using specialized approaches that are not feasible in the major reference databases. Many are labors of love, run by a single lab with little or no dedicated funding and there are many challenges to building and maintaining them. This perspective arose from a meeting of several specialist protein resources and major reference databases held at the Wellcome Trust Genome Campus (Cambridge, UK) on August 11 and 12, 2014. During this meeting some common key challenges involved in creating and maintaining such resources were discussed, along with various approaches to address them. In laying out these challenges, we aim to inform users about how these issues impact our resources and illustrate ways in which our working together could enhance their accuracy, currency, and overall value. Proteins 2015; 83:1005-1013. (c) 2015 The Authors. Proteins: Structure, Function, and Bioinformatics Published by Wiley Periodicals, Inc.

Item Type: Editorials/Short Communications
Additional Information: Copy right for this article belongs to the WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Keywords: specialist protein resource; key challenges; biocuration; longevity; big data; misannotation
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 22 Jun 2015 05:20
Last Modified: 22 Jun 2015 05:20
URI: http://eprints.iisc.ac.in/id/eprint/51724

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