Rangaswamy, J and Kumar, Vijay H and Harini, ST and Naik, Nagaraja (2015) An Easy Access to Benzofurans via DBU Induced Condensation Reaction of Active 2-Hydroxy Acetophenones with Phenacyl Chlorides: A Novel Class of Antioxidant Agents. In: JOURNAL OF HETEROCYCLIC CHEMISTRY, 52 (3). pp. 938-943.
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A convenient and efficient one-pot synthesis of benzofurans 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 3k, 3l, 3m, 3n, 3o, 3p, 3q, 3r, 3s, 3t has been described from 2-hydroxy acetophenones and phenacyl chlorides in the presence of DBU. The procedure was applicable for a variety of phenacyl chlorides and provides a variety of benzofurans with higher yields. DBU acts as a base and as well as nucleophiles. All the derivatives were subjected to in vitro antioxidant screenings against representative 2,2-diphenyl-1-picryl-hydrazyl and 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radicals and results worth for further investigations.
| Item Type: | Journal Article |
|---|---|
| Publication: | JOURNAL OF HETEROCYCLIC CHEMISTRY |
| Publisher: | WILEY-BLACKWELL |
| Additional Information: | Copy right for this article belongs to the WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 15 Jun 2015 05:52 |
| Last Modified: | 15 Jun 2015 05:52 |
| URI: | http://eprints.iisc.ac.in/id/eprint/51648 |
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