Graphene oxide-Fe3O4 nanoparticle composite with high transverse proton relaxivity value for magnetic resonance imaging

Venkatesha, N and Poojar, Pavan and Qurishi, Yasrib and Geethanath, Sairam and Srivastava, Chandan (2015) Graphene oxide-Fe3O4 nanoparticle composite with high transverse proton relaxivity value for magnetic resonance imaging. In: JOURNAL OF APPLIED PHYSICS, 117 (15).

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Abstract

The potential of graphene oxide-Fe3O4 nanoparticle (GO-Fe3O4) composite as an image contrast enhancing material in magnetic resonance imaging has been investigated. Proton relaxivity values were obtained in three different homogeneous dispersions of GO-Fe3O4 composites synthesized by precipitating Fe3O4 nanoparticles in three different reaction mixtures containing 0.01 g, 0.1 g, and 0.2 g of graphene oxide. A noticeable difference in proton relaxivity values was observed between the three cases. A comprehensive structural and magnetic characterization revealed discrete differences in the extent of reduction of the graphene oxide and spacing between the graphene oxide sheets in the three composites. The GO-Fe3O4 composite framework that contained graphene oxide with least extent of reduction of the carboxyl groups and largest spacing between the graphene oxide sheets provided the optimum structure for yielding a very high transverse proton relaxivity value. It was found that the GO-Fe3O4 composites possessed good biocompatibility with normal cell lines, whereas they exhibited considerable toxicity towards breast cancer cells. (C) 2015 AIP Publishing LLC.

Item Type:	Journal Article
Publication:	JOURNAL OF APPLIED PHYSICS
Publisher:	AMER INST PHYSICS
Additional Information:	Copy right for this article belongs to the AMER INST PHYSICS, 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
Keywords:	MRI CONTRAST AGENTS; IRON-OXIDE NANOPARTICLES; FE3O4 NANOPARTICLES; FERRITE NANOPARTICLES; WATER EXCHANGE; PARTICLE-SIZE
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	22 May 2015 07:25
Last Modified:	22 May 2015 07:25
URI:	http://eprints.iisc.ac.in/id/eprint/51561

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