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Central conduction in Leprosy - a multidomain study

Srinivasan, TM and Ramakrishnan, AG (1992) Central conduction in Leprosy - a multidomain study. In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, October 29 –Nov.1, 1992, Paris, France, V.14 2491-2492.


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Thia paper reports the findings of a pioneering study of central conduction in 21 leprosy patients. Somatosensory evoked potentials (SEP) and compound nerve action potentials (CNAP) are recorded after electrical stiaulation of median nerves of subjects. The data fro* both the SKPs and the CNAPs were subjected to time domain, frequency domain and discriainant analyses. The amplitudes and power spectra of the SKPs and the discriminating power of the central conduction time unambiguously prove that the central nervous system (CNS) is spared in leprosy. In contrast, the significant changes in the characteristics of CNAPs indicate a high degree of peripheral nerve abnormality. Thus, that the mycobac-terium leprae do not infect the CNS is electrophysio-logically established for the first time.

Item Type: Conference Paper
Publisher: IEEE
Additional Information: ©1992 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
Department/Centre: Division of Electrical Sciences > Electrical Engineering
Date Deposited: 05 Jul 2004
Last Modified: 19 Sep 2010 04:13
URI: http://eprints.iisc.ac.in/id/eprint/512

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