Cells Producing Their Own Nemesis: Understanding Methylglyoxal Metabolism

Chakraborty, Sangeeta and Karmakar, Kapudeep and Chakravortty, Dipshikha (2014) Cells Producing Their Own Nemesis: Understanding Methylglyoxal Metabolism. In: IUBMB LIFE, 66 (10). pp. 667-678.

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Abstract

Methylglyoxal, which is technically known as 2-oxopropanal or pyruvaldehyde, shows typical reactions of carbonyl compounds as it has both an aldehyde and a ketone functional group. It is an extremely cytotoxic physiological metabolite, which is generated by both enzymatic and nonenzymatic reactions. The deleterious nature of the compound is due to its ability to glycate and crosslink macromolecules like protein and DNA, respectively. However, despite having toxic effects on cellular processes, methylglyoxal retains its efficacy as an anticancer drug. Indeed, methylglyoxal is one of the well-known anticancer therapeutic agents used in the treatment. Several studies on methylglyoxal biology revolve around the manifestations of its inhibitory effects and toxicity in microbial growth and diabetic complications, respectively. Here, we have revisited the chronology of methylglyoxal research with emphasis on metabolism of methylglyoxal and implications of methylglyoxal production or detoxification on bacterial pathogenesis and disease progression. (C) 2014 IUBMB Life, 66(10): 667-678, 2014

Item Type:	Journal Article
Publication:	IUBMB LIFE
Publisher:	WILEY-BLACKWELL
Additional Information:	Copy right for this article belongs to the WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Keywords:	methylglyoxal metabolism; AGEs; glyoxalase; bacterial pathogenesis; anti-cancer agent
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	06 Feb 2015 15:00
Last Modified:	06 Feb 2015 15:00
URI:	http://eprints.iisc.ac.in/id/eprint/50787

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