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Recent NMR Methodological Developments for Chiral Analysis in Isotropic Solutions

Chaudhari, Sachin Rama and Suryaprakash, N (2014) Recent NMR Methodological Developments for Chiral Analysis in Isotropic Solutions. In: JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE, 94 (4). pp. 485-515.

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Chiral auxiliaries are used for NMR spectroscopic study of enantiomers. Often the presence of impurities, severe overlap of peaks, excessive line broadening and complex multiplicity pattern restricts the chiral analysis using 1D H-1 NMR spectrum. There are few approaches to resolve the overlapped peaks. One approach is to use suitable chiral auxiliary, which induces large chemical shift difference between the discriminated peaks (Delta delta(R,S)) and minimize the overlap. Another direction of approach is to design appropriate NMR experiments to circumvent some of these problems, viz, enhancing spectral resolution, unravelling the superimposed spectra of enantiomers, and reduction of spectral complexity. Large number of NMR techniques, such as two dimensional selective F-1 decoupling, RES-TOCSY, multiple quantum detection, frequency selective homodecoupling, band selective homodecoupling, broadband homodecoupling, etc. have been reported for such a purpose. Many of these techniques have aided in chiral analysis for molecules of diverse functionality in the presence of chiral auxiliaries. The present review summarizes the recently reported NMR experimental methodologies, with a special emphasis on the work carried out in authors' laboratory.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the INDIAN INST SCIENCE, INDIAN INST SCIENCE, BANGALORE 560012, INDIA
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited: 13 Jan 2015 04:51
Last Modified: 13 Jan 2015 04:51
URI: http://eprints.iisc.ac.in/id/eprint/50644

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