A metal-free and a solvent-free synthesis of thio-amides and amides: an efficient Friedel-Crafts arylation of isothiocyanates and isocyanates

Varun, Begur Vasanthkumar and Sood, Ankush and Prabhu, Kandikere Ramaiah (2014) A metal-free and a solvent-free synthesis of thio-amides and amides: an efficient Friedel-Crafts arylation of isothiocyanates and isocyanates. In: RSC ADVANCES, 4 (105). pp. 60798-60807.

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Abstract

A rapid, metal-free and solvent-free (very low loading of solvent in few cases) reaction conditions for synthesizing thioamides and amides using a Bronsted super acid such as triflic acid has been developed. This method shows a broad substrate scope with a variety of electron-rich arenes including thiophene derivatives. The reaction works well for both aromatic as well as aliphatic isothiocyanates. Most of the thioamides are obtained in excellent yields in short reaction times and in most of the examples, a simple work up procedure has been developed which does not require further purification.

Item Type:	Journal Article
Publication:	RSC ADVANCES
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	Copyright for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	12 Jan 2015 07:26
Last Modified:	12 Jan 2015 07:26
URI:	http://eprints.iisc.ac.in/id/eprint/50617

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