Polyester derived from recycled poly(ethylene terephthalate) waste for regenerative medicine

Sarkar, Kishor and Meka, Sai Rama Krishna and Bagchi, Amrit and Krishna, NS and Ramachandra, SG and Madras, Giridhar and Chatterjee, Kaushik (2014) Polyester derived from recycled poly(ethylene terephthalate) waste for regenerative medicine. In: RSC ADVANCES, 4 (102). pp. 58805-58815.

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Abstract

Despite advances in regenerative medicine, the cost of such therapies is beyond the reach of many patients globally in part due to the use of expensive biomedical polymers. Large volumes of poly(ethylene terephthalate) (PET) in municipal waste is a potential source of low cost polymers. A novel polyester was prepared by a catalyst-free, melt polycondensation reaction of bis(hydroxyethylene) terephthalate derived from PET post-consumer waste with other multi-functional monomers from renewable sources such as citric acid, sebacic acid and D-mannitol. The mechanical properties and degradation rate of the polyester can be tuned by varying the composition and the post-polymerization time. The polyester was found to be elastomeric, showed excellent cytocompatibility in vitro and elicited minimal immune response in vivo. Three-dimensional porous scaffolds facilitated osteogenic differentiation and mineralization. This class of polyester derived from low cost, recycled waste and renewable sources is a promising candidate for use in regenerative medicine.

Item Type:	Journal Article
Publication:	RSC ADVANCES
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	Copyright for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre:	Division of Mechanical Sciences > Chemical Engineering Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	12 Jan 2015 07:22
Last Modified:	12 Jan 2015 07:22
URI:	http://eprints.iisc.ac.in/id/eprint/50616

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