Covalent assembly-disassembly of poly(ether imine) dendritic macromolecular monomers and megamers

Bagul, Rahul S and Jayaraman, Narayanaswamy (2014) Covalent assembly-disassembly of poly(ether imine) dendritic macromolecular monomers and megamers. In: POLYMER, 55 (20). pp. 5102-5110.

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Abstract

Poly(ether imine) dendritic macromolecules were undertaken to study the reversible dendrimer monomer-megamer assembly-disassembly in aqueous solutions. Synthesis of thiol functionalized poly(ether imine) (PETIM) dendrimers and their covalent aggregation behavior in the aqueous solution of ethanol/water (2:1) is demonstrated. The dendritic megamers were characterized using microscopic techniques. Kinetics of the aggregation behavior was followed using turbidity measurements, light-scattering and atomic force microscopic techniques. Inherent luminescence behavior of PETIM dendrimer monomers was retained in the dendrimer megamers also, which allowed visualization of the megamers through confocal microscopy. Extent of thiol functionalities that remained after the megamer assembly was estimated through Ellman's assay. Subsequent to megamer assembly, disassembly of megamers to dendrimer monomers was conducted, using dithiothreitol reagent. Water-insoluble sudan I dye was encapsulated in dendrimer megamer and subsequent release profile was assessed during the disassembly in aqueous solutions. The studies were conducted using first, second and third generations, representing 4, 8 and 16 sulfhydryl groups at their peripheries of dendrimers, respectively. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Publication:	POLYMER
Publisher:	ELSEVIER SCI LTD
Additional Information:	Copyright for his article belongs to the ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
Keywords:	Dendrimers; Host-guest interactions; Thiol-disulfide interchange
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	12 Jan 2015 05:58
Last Modified:	12 Jan 2015 05:58
URI:	http://eprints.iisc.ac.in/id/eprint/50592

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