Studying Microstructure in Molecular Crystals With Nanoindentation: Intergrowth Polymorphism in Felodipine

Mishra, Manish Kumar and Desiraju, Gautam R and Ramamurty, Upadrasta and Bond, Andrew D (2014) Studying Microstructure in Molecular Crystals With Nanoindentation: Intergrowth Polymorphism in Felodipine. In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53 (48). pp. 13102-13105.

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Abstract

Intergrowth polymorphism refers to the existence of distinct structural domains within a single crystal of a compound. The phenomenon is exhibited by form II of the active pharmaceutical ingredient felodipine, and the associated microstructure is a significant feature of the compound's structural identity. Employing the technique of nanoindentation on form II reveals a bimodal mechanical response on specific single-crystal faces, demonstrating distinct properties for two polymorphic forms within the same crystal.

Item Type:	Journal Article
Publication:	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Publisher:	WILEY-V C H VERLAG GMBH
Additional Information:	Copyright for this article belongs to the WILEY-V C H VERLAG GMBH, BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
Keywords:	crystal engineering; microstructure; nanoindentation; polymorphism; X-ray diffraction
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	12 Jan 2015 05:10
Last Modified:	12 Jan 2015 05:10
URI:	http://eprints.iisc.ac.in/id/eprint/50571

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