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Biocompatible and Antibacterial SnO2 Nanowire Films Synthesized by E-Beam Evaporation Method

Prasad, RGSV and Phani, AR and Rao, KN and Kumar, Rakesh R and Prasad, S and Prabhakara, G and Sheeja, MS and Salins, CP and Endrino, JL and Raju, DB (2014) Biocompatible and Antibacterial SnO2 Nanowire Films Synthesized by E-Beam Evaporation Method. In: JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 11 (6). pp. 942-950.

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Official URL: http://dx.doi.org/ 10.1166/jbn.2015.2025


In this work, the biocompatibility and antibacterial activities of novel SnO2 nanowire coatings prepared by electron-beam (E-Beam) evaporation process at low temperatures were studied. The nanowire coatings were characterized by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), and X-ray diffraction (XRD) methods. The results of in vitro cytotoxicity and cell proliferation assays suggested that the SnO2 nanowire coatings were nontoxic and promoted the proliferation of C2C12 and L929 cells (> 90% viability). Cellular activities, cell adhesion, and lactate dehydrogenase activities were consistent with the superior biocompatibility of the nanowire materials. Notably, the nanowire coating showed potent antibacterial activity against six different bacterial strains. The antibacterial activity of the SnO2 material was attributed to the photocatalytic nature of SnO2. The antibacterial activity and biocompatibility of the newly developed SnO2 nanowire coatings may enable their use as coating materials for biomedical implants.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the AMER SCIENTIFIC PUBLISHERS, 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
Keywords: SnO2 NWs; Cytotoxicity; Cell Proliferation; Antibacterial Activity
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 29 Dec 2014 05:53
Last Modified: 29 Dec 2014 05:53
URI: http://eprints.iisc.ac.in/id/eprint/50553

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