Synthesis and Antioxidant Activities of Novel Chiral Ebselen Analogues

Elsherbini, Mohamed and Hamama, Wafaa S and Zoorob, Hanafi H and Bhowmick, Debasish and Mugesh, Govindasamy and Wirth, Thomas (2014) Synthesis and Antioxidant Activities of Novel Chiral Ebselen Analogues. In: HETEROATOM CHEMISTRY, 25 (5, SI). pp. 320-325.

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Abstract

Novel chiral analogues of the antioxidant, anti-inflammatory organoselenium drug ebselen were synthesized. The reaction proceeded readily from 2-(chloroseleno)benzoyl chloride with chiral amino compounds. The chiral substituent on the nitrogen atom did not provide a substantial increase in activities and the newly synthesized compounds showed similar activities to ebselen.

Item Type:	Journal Article
Publication:	HETEROATOM CHEMISTRY
Publisher:	WILEY-BLACKWELL
Additional Information:	Copyright for this article belongs to the WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	20 Dec 2014 04:25
Last Modified:	20 Dec 2014 04:25
URI:	http://eprints.iisc.ac.in/id/eprint/50474

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