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Combinatorial Approach to Develop Tailored Biodegradable Poly(xylitol dicarboxylate) Polyesters

Dasgupta, Queeny and Chatterjee, Kaushik and Madras, Giridhar (2014) Combinatorial Approach to Develop Tailored Biodegradable Poly(xylitol dicarboxylate) Polyesters. In: BIOMACROMOLECULES, 15 (11). pp. 4302-4313.

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Official URL: http://dx.doi.org/ 10.1021/bm5013025


The objective of this work was to develop a versatile strategy for preparing biodegradable polymers with tunable properties for biomedical applications. A family of xylitol-based cross-linked polyesters was synthesized by melt condensation. The effect of systematic variation of chain length of the diacid, stoichiometric ratio, and postpolymerization curing time on the physicochemical properties was characterized. The degradation rate decreased as the chain length of the diacid increased. The polyesters synthesized by this approach possess a diverse spectrum of degradation (ranging from similar to 4 to 100% degradation in 7 days), mechanical strength (from 0.5 to similar to 15 MPa) and controlled release properties. The degradation was a first-order process and the rate constant of degradation decreased linearly as the hydrophobicity of the polyester increased. In controlled release studies, the order of diffusion increased with chain length and curing time. The polymers were found to be cytocompatible and are thus suitable for possible use as biodegradable polymers. This work demonstrates that this particular combinatorial approach to polymer synthesis can be used to prepare biomaterials with independently tunable properties.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre: Division of Mechanical Sciences > Chemical Engineering
Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 20 Dec 2014 04:13
Last Modified: 20 Dec 2014 04:13
URI: http://eprints.iisc.ac.in/id/eprint/50467

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