Effect of inductive effect on the formation of cocrystals and eutectics

Prasad, Karothu Durga and Cherukuvada, Suryanarayan and Stephen, Devaraj L and Row, Tayur Guru N (2014) Effect of inductive effect on the formation of cocrystals and eutectics. In: CRYSTENGCOMM, 16 (42). pp. 9930-9938.

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Abstract

There is a growing need to understand the factors that control the formation of different yet related multicomponent adducts such as cocrystals, solid solutions and eutectics from both fundamental and application perspectives. Benzoic acid and its structural analogues, having gradation in inductive force strengths, are found to serve as excellent coformers to comprehend the formation of above adducts with the antiprotozoal drug ornidazole. The combination of the drug with para-amino and -hydroxybenzoic acids resulted in cocrystals in accordance with the induction strength complementarity between the participant hydrogen bond donor-acceptor groups. The lack of adequate inductive forces for combinations with benzoic acid and other coformers was exploited to make eutectics of the drug. The isomorphous/isostructural relationship between para-amino and -hydroxybenzoic acid-drug cocrystals was utilized to make solid solutions, i.e. solid solutions of cocrystals. All in all, we successfully steered and expanded the supramolecular solid-form space of ornidazole.

Item Type:	Journal Article
Publication:	CRYSTENGCOMM
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	04 Dec 2014 04:50
Last Modified:	04 Dec 2014 04:50
URI:	http://eprints.iisc.ac.in/id/eprint/50376

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