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Cancer gene signatures in risk stratification: use in personalized medicine

Shukla, Sudhanshu and Bhargava, Shruti and Somasundaram, Kumaravel (2014) Cancer gene signatures in risk stratification: use in personalized medicine. In: CURRENT SCIENCE, 107 (5). pp. 815-823.

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Official URL: http://www.currentscience.ac.in/Volumes/107/05/081...


Cancer is a complex disease which arises due to a series of genetic changes related to cell division and growth control. Cancer remains the second leading cause of death in humans next to heart diseases. As a testimony to our progress in understanding the biology of cancer and developments in cancer diagnosis and treatment methods, the overall median survival time of all cancers has increased six fold one year to six years during the last four decades. However, while the median survival time has increased dramatically for some cancers like breast and colon, there has been only little change for other cancers like pancreas and brain. Further, not all patients having a single type of tumour respond to the standard treatment. The differential response is due to genetic heterogeneity which exists not only between tumours, which is called intertumour heterogeneity, but also within individual tumours, which is called intratumoural heterogeneity. Thus it becomes essential to personalize the cancer treatment based on a specific genetic change in a given tumour. It is also possible to stratify cancer patients into low- and high-risk groups based on expression changes or alterations in a group of genes gene signatures and choose a more suitable mode of therapy. It is now possible that each tumour can be analysed using various high-throughput methods like gene expression profiling and next-generation sequencing to identify its unique fingerprint based on which a personalized or tailor-made therapy can be developed. Here, we review the important progress made in the recent years towards personalizing cancer treatment with the use of gene signatures.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the INDIAN ACAD SCIENCES, C V RAMAN AVENUE, SADASHIVANAGAR, P B #8005, BANGALORE 560 080, INDIA
Keywords: Biomarker; cancer; molecular signature; personalized medicine
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 12 Nov 2014 05:20
Last Modified: 12 Nov 2014 05:20
URI: http://eprints.iisc.ac.in/id/eprint/50230

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