ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

3 `-Amino-5 `-carboxymethy1-3 `,5 `-dideoxy nucleosides for the synthesis of fully amide-linked RNA mimics

Sunkari, Yashoda Krishna and Pal, Chandan and Reddy, Thota Jagadeshwar and Chakraborty, Tushar Kanti (2014) 3 `-Amino-5 `-carboxymethy1-3 `,5 `-dideoxy nucleosides for the synthesis of fully amide-linked RNA mimics. In: TETRAHEDRON, 70 (35). pp. 5455-5462.

[img] PDF
tet_70-35_5455_2014.pdf - Published Version
Restricted to Registered users only

Download (656kB) | Request a copy
Official URL: http://dx.doi.org/ 10.1016/j.tet.2014.06.119


A convenient protocol is developed for the synthesis of 3 `-N-(fluorenylmethoxycarbonyl)-amino]-5 `-carboxymethyl derivatives of all four natural ribonucleosides from cheap chiral pool compound glucose. Synthesis of fully amide-linked RNA analogues of small oligonucleotides containing, for the first time, all four nucleoside amino acids using standard solid phase Fmoc-chemistry is described. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Publication: TETRAHEDRON
Additional Information: Copy right for this article belongs to the PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 18 Sep 2014 09:08
Last Modified: 18 Sep 2014 09:08
URI: http://eprints.iisc.ac.in/id/eprint/49884

Actions (login required)

View Item View Item