Sunkari, Yashoda Krishna and Pal, Chandan and Reddy, Thota Jagadeshwar and Chakraborty, Tushar Kanti (2014) 3 `-Amino-5 `-carboxymethy1-3 `,5 `-dideoxy nucleosides for the synthesis of fully amide-linked RNA mimics. In: TETRAHEDRON, 70 (35). pp. 5455-5462.
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Abstract
A convenient protocol is developed for the synthesis of 3 `-N-(fluorenylmethoxycarbonyl)-amino]-5 `-carboxymethyl derivatives of all four natural ribonucleosides from cheap chiral pool compound glucose. Synthesis of fully amide-linked RNA analogues of small oligonucleotides containing, for the first time, all four nucleoside amino acids using standard solid phase Fmoc-chemistry is described. (C) 2014 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Publication: | TETRAHEDRON |
| Additional Information: | Copy right for this article belongs to the PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 18 Sep 2014 09:08 |
| Last Modified: | 18 Sep 2014 09:08 |
| URI: | http://eprints.iisc.ac.in/id/eprint/49884 |
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