Role of surface chemistry in modulating drug release kinetics in titania nanotubes

Mandal, Soumit S and Jose, Deena and Bhattacharyya, Aninda J (2014) Role of surface chemistry in modulating drug release kinetics in titania nanotubes. In: MATERIALS CHEMISTRY AND PHYSICS, 147 (1-2). pp. 247-253.

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Abstract

Surface chemistry and the intrinsic porous architectures of porous substrates play a major role in the design of drug delivery systems. An interesting example is the drug elution characteristic from hydrothermally synthesised titania nanotubes with tunable surface chemistry. The variation in release rates of Ibuprofen (IBU) is largely influenced by the nature of the functional groups on titania nanotubes and pH of suspending medium. To elucidate the extent of interaction between the encapsulated IBU and the functional groups on titania nanotubes, the release profiles have been modelled with an empirical Hill equation. The analysis aided in establishing a probable mechanism for the release of IBU from the titania nanotubes. The study of controlled drug release from TiO2 has wider implication in the context of biomedical engineering. (C) 2014 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Publication:	MATERIALS CHEMISTRY AND PHYSICS
Publisher:	ELSEVIER SCIENCE SA
Additional Information:	copyright for this article belongs to ELSEVIER SCIENCE SA, PO BOX 564, 1001 LAUSANNE, SWITZERLAND
Keywords:	Biomaterials; Nanostructures; Surface properties; Diffusion
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	19 Aug 2014 11:09
Last Modified:	19 Aug 2014 11:09
URI:	http://eprints.iisc.ac.in/id/eprint/49615

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