Monte Carlo simulation of light transport in turbid medium with embedded object-spherical, cylindrical, ellipsoidal, or cuboidal objects embedded within multilayered tissues

Periyasamy, Vijitha and Pramanik, Manojit (2014) Monte Carlo simulation of light transport in turbid medium with embedded object-spherical, cylindrical, ellipsoidal, or cuboidal objects embedded within multilayered tissues. In: JOURNAL OF BIOMEDICAL OPTICS, 19 (4).

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Abstract

Monte Carlo modeling of light transport in multilayered tissue (MCML) is modified to incorporate objects of various shapes (sphere, ellipsoid, cylinder, or cuboid) with a refractive-index mismatched boundary. These geometries would be useful for modeling lymph nodes, tumors, blood vessels, capillaries, bones, the head, and other body parts. Mesh-based Monte Carlo (MMC) has also been used to compare the results from the MCML with embedded objects (MCML-EO). Our simulation assumes a realistic tissue model and can also handle the transmission/reflection at the object-tissue boundary due to the mismatch of the refractive index. Simulation of MCML-EO takes a few seconds, whereas MMC takes nearly an hour for the same geometry and optical properties. Contour plots of fluence distribution from MCML-EO and MMC correlate well. This study assists one to decide on the tool to use for modeling light propagation in biological tissue with objects of regular shapes embedded in it. For irregular inhomogeneity in the model (tissue), MMC has to be used. If the embedded objects (inhomogeneity) are of regular geometry (shapes), then MCML-EO is a better option, as simulations like Raman scattering, fluorescent imaging, and optical coherence tomography are currently possible only with MCML. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)

Item Type:	Journal Article
Publication:	JOURNAL OF BIOMEDICAL OPTICS
Publisher:	SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
Additional Information:	Copy right for this article belongs to the SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS, 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
Keywords:	Monte Carlo simulation; mesh-based Monte Carlo; Monte Carlo modeling; light transport; multilayered tissues; embedded objects
Department/Centre:	Division of Electrical Sciences > Electrical Engineering
Date Deposited:	19 Aug 2014 09:13
Last Modified:	19 Aug 2014 09:13
URI:	http://eprints.iisc.ac.in/id/eprint/49567

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