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Toward the total synthesis of a lagunamide B analogue

Pal, Sudip and Chakraborty, Tushar Kanti (2014) Toward the total synthesis of a lagunamide B analogue. In: TETRAHEDRON LETTERS, 55 (24). pp. 3469-3472.

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Official URL: http://dx.doi.org/10.1016/j.tetlet.2014.04.079


Lagunamides, isolated from a marine cyanobacterium Lyngbya majuscule found in Singapore, showed very potent activities against Plasmodium falciparum and murine leukemia cell line (P388). Herein, a concise synthetic approach toward the total synthesis of a lagunamide B analogue is discussed. Macrolactonization, HWE-olefination, and modified Crimmin's aldol are some of the key reactions featured in this synthesis. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Keywords: Macrolactonization; Macrolactamization; Horner-Wadsworth-Emmons olefination; Crimmin's aldol; 2-Methyl-6-nitrobenzoic anhydride (MNBA)
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 14 Aug 2014 10:06
Last Modified: 14 Aug 2014 10:06
URI: http://eprints.iisc.ac.in/id/eprint/49553

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