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Photonic Hydrogel Beads for Controlled Release of Risedronate

Khajuria, Deepak Kumar and Mahapatra, Roy D (2014) Photonic Hydrogel Beads for Controlled Release of Risedronate. In: Conference on Photonic Therapeutics and Diagnostics X, FEB 01-02, 2014, San Francisco, CA.

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Official URL: http://dx.doi.org/10.1117/12.2042568


pH-sensitive photonic composite hydrogel beads composed of sodium alginate and risedronate sodium (SA/RIS) was prepared crosslinked by Ca2+ owing to the ionic gelation of SA. The structure and surface morphology of the composite hydrogel beads were characterized by SEM. pH-sensitivity of these composite hydrogels beads and the release behaviors of drug from them were investigated. The results showed that the composite hydrogel beads had good pH-sensitivity. The drug loading and encapsulation efficiency were 27.7% and 92% for RIS, respectively. The cumulative release ratios of RIS from the composite hydrogel beads were 2.47% in pH 2.1 solution and 83 % in pH 6.8 solutions within 24 h, respectively. However, the cumulative release ratio of RIS in pH 7.4 solution reached 91% within 7 h. It is proposed that the novel photonic SA/RIS composite hydrogel bead could possess the potential of an increased intestinal absorption and fewer adverse effects of RIS. The pH and salt response of photonic hydrogel bead, as well as the encapsulation of macromolecules, are promising for applications in biomedicine and biotechnology.

Item Type: Conference Proceedings
Series.: Proceedings of SPIE
Additional Information: Copyright for this article belongs to the SPIE-INT SOC OPTICAL ENGINEERING, 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
Keywords: Hydrogel; Sodium alginate; Risedronate; Bisphosphonate; Drug release; Osteoporosis; Fluorescence
Department/Centre: Division of Mechanical Sciences > Aerospace Engineering(Formerly Aeronautical Engineering)
Date Deposited: 25 Jul 2014 04:39
Last Modified: 25 Jul 2014 04:39
URI: http://eprints.iisc.ac.in/id/eprint/49523

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