Srivastava, Nishit and James, Jackson and Narayan, KS (2014) Morphology and electrostatics play active role in neuronal differentiation processes on flexible conducting substrates. In: ORGANOGENESIS, 10 (1). pp. 1-5.
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This commentary discusses and summarizes the key highlights of our recently reported work entitled ``Neuronal Differentiation of Embryonic Stem Cell Derived Neuronal Progenitors Can Be Regulated by Stretchable Conducting Polymers.'' The prospect of controlling the mechanical-rigidity and the surface conductance properties offers a unique combination for tailoring the growth and differentiation of neuronal cells. We emphasize the utility of transparent elastomeric substrates with coatings of electrically conducting polymer to realize the desired substrate-characteristics for cellular development processes. Our study showed that neuronal differentiation from ES cells is highly influenced by the specific substrates on which they are growing. Thus, our results provide a better strategy for regulated neuronal differentiation by using such functional conducting surfaces.
| Item Type: | Journal Article |
|---|---|
| Publication: | ORGANOGENESIS |
| Publisher: | LANDES BIOSCIENCE |
| Additional Information: | copyright for this article belongs to LANDES BIOSCIENCE, 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA |
| Keywords: | electrostatics; cell differentiation; neuronal cells; stretched substrates; conducting polymers |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 18 Jun 2014 03:51 |
| Last Modified: | 18 Jun 2014 03:51 |
| URI: | http://eprints.iisc.ac.in/id/eprint/49266 |
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