Iron(III) benzhydroxamates of dipicolylamines for photocytotoxicity in red light and cellular imaging

Garai, Aditya and Basu, Uttara and Khan, Imran and Pant, Ila and Hussain, Akhtar and Kondaiah, Paturu and Chakravarty, Akhil R (2014) Iron(III) benzhydroxamates of dipicolylamines for photocytotoxicity in red light and cellular imaging. In: POLYHEDRON, 73 . pp. 124-132.

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Abstract

Benzhydroxamate (BHA) iron(III) complexes Fe(BHA)(L)ClICI (I, 2)], where L is (phenyl)dipicolylamine (phdpa in I) and (pyrenyl)dipicolylamine (pydpa in 2), were prepared and their photocytotoxicity in visible (400-700 nm) and red (600-720 nm) light was studied. Complex 1 was structurally characterized by X-ray crystallography. The complexes have high-spin iron(III) centers. Complex 2, with a pyrenyl fluorophore, was used for cellular imaging, showing both mitochondrial and nuclear localization in the fluorescence microscopic study. The complex exhibited photocytotoxicity in red light in HeLa cancer cells, giving IC50 value of 24.4(+/- 0.4) pM, but remained essentially non-toxic in the dark. The involvement of reactive oxygen species and an apoptotic nature of cell death were observed from the cellular studies. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Publication:	POLYHEDRON
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Additional Information:	Copyright for this article belongs to the PERGAMON-ELSEVIER SCIENCE LTD, ENGLAND
Keywords:	Iron; Dipicolylamine bases; Hydroxamate; Crystal structure; Photocytotoxicity; Cellular imaging
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	11 Jun 2014 09:37
Last Modified:	11 Jun 2014 09:37
URI:	http://eprints.iisc.ac.in/id/eprint/49163

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