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Formal Synthesis of Actin Binding Macrolide Rhizopodin

Pulukuri, KK and Chakraborty, TK (2014) Formal Synthesis of Actin Binding Macrolide Rhizopodin. In: ORGANIC LETTERS, 16 (8). pp. 2284-2287.

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Official URL: http://dx.doi.org/10.1021/ol5008179


Formal synthesis, of an actin binding macrolide rhizopodin was achieved in 19 longest linear steps. The key features of the synthesis include a stereoselective Mukaiyama aldol reaction, dual role of a Nagao auxiliary (first, as a chiral auxiliary of choice for installing hydroxy centers and, later, as an acylating agent to form an amide bond with an amino alcohol), late stage oxazole formation, and Stille coupling reactions.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to AMER CHEMICAL SOC, USA.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 10 Jun 2014 11:02
Last Modified: 10 Jun 2014 11:02
URI: http://eprints.iisc.ac.in/id/eprint/49121

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