RES-TOCSY: a simple approach to resolve overlapped H-1 NMR spectra of enantiomers

Lokesh, Lokesh and Chaudhari, Sachin Rama and Suryaprakash, N (2014) RES-TOCSY: a simple approach to resolve overlapped H-1 NMR spectra of enantiomers. In: ORGANIC & BIOMOLECULAR CHEMISTRY, 12 (6). pp. 993-997.

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Abstract

Chiral auxiliaries are used for the NMR spectroscopic study of enantiomers. Often the presence of impurities, overlap of peaks, line broadening and the multiplicity pattern restrict the chiral analysis in the 1D H-1 NMR spectrum. The present study introduces a simple 2D H-1 NMR experiment to unravel the overlapped spectrum. The experiment separates the spectra of enantiomers, thereby allowing the unambiguous assignment of all the coupled peaks and the measurement of enantiomeric excess (ee) from a single experiment even in combinatorial mixtures.

Item Type:	Journal Article
Publication:	ORGANIC & BIOMOLECULAR CHEMISTRY
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	Copyright for this article belongs to the ROYAL SOC CHEMISTRY, ENGLAND
Department/Centre:	Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility) Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	14 Mar 2014 10:10
Last Modified:	14 Mar 2014 10:10
URI:	http://eprints.iisc.ac.in/id/eprint/48567

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