Comparative Evaluation of Zoledronic Acid, Alfacalcidol and Propranolol in Pharmacological Correction of Experimental Osteoporosis

Khajuria, Deepak Kumar and Disha, Choudhary and Razdan, Rema and Mahapatra, Debiprasad R and Bhat, Moodabidri R (2013) Comparative Evaluation of Zoledronic Acid, Alfacalcidol and Propranolol in Pharmacological Correction of Experimental Osteoporosis. In: LATIN AMERICAN JOURNAL OF PHARMACY, 32 (7). pp. 968-976.

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Abstract

Propranolol, a beta-adrenergic receptor blocker, is presently considered to be a potential therapeutic intervention under investigation for its role in prevention and treatment of osteoporosis. However, no studies have compared the osteoprotective properties of propranolol with well accepted therapeu-tic interventions for the treatment of osteoporosis. To address this question, this study was designed to evaluate the bone protective effects of zoledronic acid, alfacalcidol and propranolol in an animal model of postmenopausal osteoporosis. Five days after ovariectomy, 36 ovariectomized (OVX) rats were divided in- to 6 equal groups, randomized to treatments zoledronic acid (100 μg/kg, intravenous single dose); alfacal-cidol (0.5 μg/kg, oral gauge daily); propranolol (0.1mg/kg, subcutaneously 5 days per week) for 12 weeks. Untreated OVX and sham OVX were used as controls. At the end of the study, rats were killed under anesthesia. For bone porosity evaluation, whole fourth lumbar vertebrae (LV4) were removed. LV4 were also used to measure bone mechanical propeties. Left femurs were used for bone histology. Propranolol showed a significant decrease in bone porosity in comparison to OVX control. Moreover, propranolol sig- nificantly improved bone mechanical properties and bone quality when compared with OVX control. The osteoprotective effect of propranolol was comparable with zoledronic acid and alfacalcidol. Based on this comparative study, the results strongly suggest that propranolol might be new therapeutic intervention for the management of postmenopausal osteoporosis in humans.

Item Type:	Journal Article
Publication:	LATIN AMERICAN JOURNAL OF PHARMACY
Publisher:	MEDKNOW PUBLICATIONS & MEDIA PVT LTD
Additional Information:	Copyright for this article belongs to the Latin American Journal of Pharmacy.
Keywords:	Alfacalcidol;Postmenopausal osteoporosis;Propranolol;Rat;Zoledronic acid
Department/Centre:	Division of Mechanical Sciences > Aerospace Engineering(Formerly Aeronautical Engineering)
Date Deposited:	17 Feb 2014 09:51
Last Modified:	06 May 2014 09:36
URI:	http://eprints.iisc.ac.in/id/eprint/48383

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