Network, nodes and nexus: systems approach to multitarget therapeutics

Murthy, Divya and Attri, Kuldeep Singh and Gokhale, Rajesh S (2013) Network, nodes and nexus: systems approach to multitarget therapeutics. In: CURRENT OPINION IN BIOTECHNOLOGY, 24 (6). pp. 1129-1136.

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Abstract

Systems biology is revealing multiple layers of regulatory networks that manifest spatiotemporal variations. Since genes and environment also influence the emergent property of a cell, the biological output requires dynamic understanding of various molecular circuitries. The metabolic networks continually adapt and evolve to cope with the changing milieu of the system, which could also include infection by another organism. Such perturbations of the functional networks can result in disease phenotypes, for instance tuberculosis and cancer. In order to develop effective therapeutics, it is important to determine the disease progression profiles of complex disorders that can reveal dynamic aspects and to develop mutitarget systemic therapies that can help overcome pathway adaptations and redundancy.

Item Type:	Journal Article
Publication:	CURRENT OPINION IN BIOTECHNOLOGY
Publisher:	CURRENT BIOLOGY LTD
Additional Information:	Copyright for this article belongs to CURRENT BIOLOGY LTD ENGLAND
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	29 Jan 2014 06:12
Last Modified:	29 Jan 2014 06:12
URI:	http://eprints.iisc.ac.in/id/eprint/48267

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