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Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation

Shigdar, Sarah and Macdonald, Joanna and O'Connor, Michael and Wang, Tao and Xiang, Dongxi and Al Shamaileh, Hadi and Qiao, Liang and Wei, Ming and Zhou, Shu-Feng and Zhu, Yimin and Kong, Lingxue and Bhattacharya, Santanu and Li, ChunGuang and Duan, Wei (2013) Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation. In: SENSORS, 13 (10). pp. 13624-13637.

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Official URL: http://dx.doi.org/10.3390/s131013624


Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.

Item Type: Journal Article
Publication: SENSORS
Publisher: MDPI AG
Additional Information: copyright for this article belongs to MDPI AG, POSTFACH,SWITZERLAND
Keywords: aptamer; SELEX; cancer; diagnostics; locked nucleic acid; unlocked nucleic acid
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 24 Jan 2014 07:11
Last Modified: 24 Jan 2014 07:11
URI: http://eprints.iisc.ac.in/id/eprint/48225

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