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Quorum sensing and pathogenesis: role of small signalling molecules in bacterial persistence

Bharati, Binod K and Chatterji, Dipankar (2013) Quorum sensing and pathogenesis: role of small signalling molecules in bacterial persistence. In: CURRENT SCIENCE, 105 (5). pp. 643-656.

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The pathogenesis of Mycobacterium tuberculosis is associated with its ability to survive inside the human host and the bacteria use a variety of mechanism to evade the host's defence. A clearer understanding of the host pathogen interaction is needed to follow the pathogenicity and virulence. Recent advances in the study of inter and intra-cellular communication in bacteria had prompted us to study the role of quorum sensing in bacterial survival and pathogenicity. The cell cell communication in bacteria (quorum sensing) is mediated through the exchange of small molecules called as autoinducers that allow bacteria to modulate their gene expression in response to change in cell-population density. It is a coordinated response that confers multicellularity to a bacterial population in response to stress from external environment. Quorum sensing molecules are the global regulators and regulate a wide range of physiological processes including biofilm formation, motility, cell differentiation, long-term survival and many others. Many bacterial pathogens require quorum sensing to produce the virulence factors in response to host pathogen interaction. Here, we summarize our current understanding on small molecule signalling and their role in the bacterial persistence. New discoveries in these areas have enriched our knowledge on intracellular signalling and their role in the long-term survival of mycobacteria under nutrient starvation.

Item Type: Journal Article
Additional Information: copyright for this article belongs to INDIAN ACAD SCIENCES
Keywords: Bacterial pathogenesis; c-di-GMP signalling; quorum sensing; second messenger; tuberculosis
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 26 Nov 2013 15:20
Last Modified: 26 Nov 2013 15:23
URI: http://eprints.iisc.ac.in/id/eprint/47796

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