Confinement induced stochastic sensing of charged coronene and perylene aggregates in alpha-hemolysin nanochannels

Shivanna, Ravichandran and Pramanik, Debabrata and Kumar, Hemant and Rao, Venkata K and George, Subi J and Maiti, Prabal K and Narayan, KS (2013) Confinement induced stochastic sensing of charged coronene and perylene aggregates in alpha-hemolysin nanochannels. In: SOFT MATTER, 9 (42). pp. 10196-10202.

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Abstract

Biological nanopores provide optimum dimensions and an optimal environment to study early aggregation kinetics of charged polyaromatic molecules in the nano-confined regime. It is expected that probing early stages of nucleation will enable us to design a strategy for supramolecular assembly and biocrystallization processes. Specifically, we have studied translocation dynamics of coronene and perylene based salts, through the alpha-hemolysin (alpha-HL) protein nanopore. The characteristic blocking events in the time-series signal are a function of concentration and bias voltage. We argue that different blocking events arise due to different aggregation processes as captured by all atomistic molecular dynamics (MD) simulations. These confinement induced aggregations of polyaromatic chromophores during the different stages of translocation are correlated with the spatial symmetry and charge distribution of the molecules.

Item Type:	Journal Article
Publication:	SOFT MATTER
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	copyright for this article belongs to ROYAL SOC CHEMISTRY
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	16 Nov 2013 13:58
Last Modified:	16 Nov 2013 13:58
URI:	http://eprints.iisc.ac.in/id/eprint/47766

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