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Evaluation of microwave assisted grafted sago starch as controlled release polymeric carrier

Singh, Akhilesh Vikram and Nath, Lila Kanta (2013) Evaluation of microwave assisted grafted sago starch as controlled release polymeric carrier. In: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 60 . pp. 62-68.

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Official URL: http://dx.doi.org/10.1016/j.ijbiomac.2013.05.008


In the present investigation an attempt has been made to develop a new co-polymeric material for controlled release tablet formulations. The acrylamide grafting was successfully performed on the backbone of sago starch. The modified starch was tested for acute toxicity and drug-excipient compatibility study. The grafted material was used in making of controlled release tablets of lamivudine. The formulations were evaluated for physical characteristics such as hardness, friability, %drug content and weight variations. The in vitro release study showed that the optimized formulation exhibited highest correlation (R) value in case of Higuchi model and the release mechanism of the optimized formulation predominantly exhibited combination of diffusion and erosion process. There was a significant difference in the pharmacokinetic parameters (T-max, C-max, AUC, V-d, T-1/2 and MDT) of the optimized formulation as compared to the marketed conventional tablet Lamivir (R) was observed. The pharmacokinetics parameters were showed controlled pattern and better bioavailability. The optimized formulation exhibited good stability and release profile at the accelerated stability conditions. (c) 2013 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Additional Information: copyright for this article belongs to ELSEVIER SCIENCE
Keywords: Lamivudine; Sago starch; Grafted copolymer; Controlled release
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 07 Nov 2013 05:57
Last Modified: 07 Nov 2013 05:57
URI: http://eprints.iisc.ac.in/id/eprint/47689

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