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Scaffolds for bone tissue engineering: role of surface patterning on osteoblast response

Mitra, Jaba and Tripathi, Garima and Sharma, Ashutosh and Basu, Bikramjit (2013) Scaffolds for bone tissue engineering: role of surface patterning on osteoblast response. In: RSC ADVANCES, 3 (28). pp. 11073-11094.

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Official URL: http://dx.doi.org/10.1039/c3ra23315d


The fabrication of tissue engineering scaffolds necessitates amalgamation of a multitude of attributes including a desirable porosity to encourage vascular invasion, desired surface chemistry for controlled deposition of calcium phosphate-based mineral as well as ability to support attachment, proliferation, and differentiation of lineage specific progenitor cells. Scaffold fabrication often includes additional surface treatments to bring about desired changes in the surface chemistry. In this perspective, this review documents the important natural and synthetic scaffolds fabricated for bone tissue engineering applications in tandem with the surface treatment techniques to maneuver the biocompatibility of engineered scaffolds. This review begins with a discussion on the fundamental concepts related to biocompatibility as well as the characteristics of the biological micro-environment. The primary focus is to discuss the effects of surface micro/nano patterning on the modulation of bone cell response. Apart from reviewing a host of experimental studies reporting the functionality of osteoblast-like bone cells and stem cells on surface modified or textured bioceramic/biopolymer scaffolds, theoretical insights to predict cell behavior on a scaffold with different topographical features are also briefly analyzed.

Item Type: Journal Article
Publication: RSC ADVANCES
Additional Information: Copyright of this article is belongs to ROYAL SOC CHEMISTRY
Department/Centre: Division of Chemical Sciences > Materials Research Centre
Date Deposited: 11 Sep 2013 05:35
Last Modified: 11 Sep 2013 05:35
URI: http://eprints.iisc.ac.in/id/eprint/47100

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