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Total Synthesis of (+)-Pinellic Acid

Sunnam, Sunil Kumar and Prasad, Kavirayani R (2013) Total Synthesis of (+)-Pinellic Acid. In: SYNTHESIS-STUTTGART, 45 (14). pp. 1991-1996.

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Official URL: http://dx.doi.org/10.1055/s-0033-1338799


A straightforward strategy for the synthesis of (+)-pinellic acid in 16% overall yield and 13 steps, starting from (1R)-1-(furan-2-yl)hexan-1-ol, is described. Key reactions in the synthesis include a Sharpless kinetic resolution, oxidation of a protected furan to reveal a but-2-ene-1,4-dione moiety, and an asymmetric reduction.

Item Type: Journal Article
Additional Information: Copyright of this article is belongs to GEORG THIEME VERLAG KG
Keywords: pinellic acid; furan oxidation; natural products; total synthesis
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 04 Sep 2013 10:37
Last Modified: 04 Sep 2013 10:37
URI: http://eprints.iisc.ac.in/id/eprint/47055

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