Total Synthesis of (+)-Pinellic Acid

Sunnam, Sunil Kumar and Prasad, Kavirayani R (2013) Total Synthesis of (+)-Pinellic Acid. In: SYNTHESIS-STUTTGART, 45 (14). pp. 1991-1996.

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Abstract

A straightforward strategy for the synthesis of (+)-pinellic acid in 16% overall yield and 13 steps, starting from (1R)-1-(furan-2-yl)hexan-1-ol, is described. Key reactions in the synthesis include a Sharpless kinetic resolution, oxidation of a protected furan to reveal a but-2-ene-1,4-dione moiety, and an asymmetric reduction.

Item Type:	Journal Article
Publication:	SYNTHESIS-STUTTGART
Publisher:	GEORG THIEME VERLAG KG
Additional Information:	Copyright of this article is belongs to GEORG THIEME VERLAG KG
Keywords:	pinellic acid; furan oxidation; natural products; total synthesis
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	04 Sep 2013 10:37
Last Modified:	04 Sep 2013 10:37
URI:	http://eprints.iisc.ac.in/id/eprint/47055

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