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Photocytotoxic ferrocene-appended (L-tyrosine)copper(II) complexes of phenanthroline bases

Goswami, Tridib K and Gadadhar, Sudarshan and Karande, Anjali A and Chakravarty, Akhil R (2013) Photocytotoxic ferrocene-appended (L-tyrosine)copper(II) complexes of phenanthroline bases. In: Polyhedron, 52 (SI). pp. 1287-1298.

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Official URL: http://dx.doi.org/10.1016/j.poly.2012.06.018


Copper(II) complexes of ferrocene(Fc)-conjugated reduced Schiff base of L-tyrosine (Fc-TyrH), viz., Cu(Fc-Tyr)(L)](ClO4), where L is 1,10-phenanthroline (phen, 1), dipyrido3,2-d:2',3'-f]quinoxaline (dpq, 2), dipyrido3,2-a:2',3'-c]phenazine (dppz, 3) and 2-(naphthalen-1-yl)-1H-imidazo4,5-f]1,10]phenanthroline (nip, 4), were prepared and tested for their photocytotoxicity in cancer cells. Cu(Fc-Phe)(phen)](-ClO4) (5) of L-phenylalanine and Cu(Ph-Tyr)(L)(ClO4)] of the reduced Schiff base Ph-TyrH derived from benzaldehyde and L-tyrosine having phen (6) and dppz (7), and Cu(Ph-Phe)(phen)(ClO4)] (8) using L-phenylalanine were prepared and used as controls. Complexes 5 and 6 were structurally characterized by X-ray crystallography. A copper(II)-based d-d band near 600 nm and a ferrocenyl band at similar to 450 nm were observed in DMF-Tris-HCI buffer (1:4 v/v) in respective complexes. The complexes are photocleavers of pUC19 DNA in visible light forming (OH)-O-center dot radicals. They are cytotoxic in HeLa (human cervical cancer) and MCF-7 (human breast cancer) cells showing an enhancement of cytotoxicity in visible light. Fluorescence imaging shows nuclear localization of the complexes.

Item Type: Journal Article
Publication: Polyhedron
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Ferrocene; Copper; Crystal Structure; DNA Photocleavage; Photocytotoxicity; Cellular Imaging
Department/Centre: Division of Biological Sciences > Biochemistry
Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 23 Jun 2013 09:42
Last Modified: 23 Jun 2013 09:42
URI: http://eprints.iisc.ac.in/id/eprint/46761

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