Synthesis, antimicrobial, DNA-binding and photonuclease studies of Cobalt(III) and Nickel(II) Schiff base complexes

Gowda, Sangeetha KR and Naik, Bhojya HS and Kumar, Vinay B and Sudhamani, CN and Sudeep, HV and Naik, Ravikumar RR and Krishnamurthy, G (2013) Synthesis, antimicrobial, DNA-binding and photonuclease studies of Cobalt(III) and Nickel(II) Schiff base complexes. In: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 105 . pp. 229-237.

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Abstract

New metal complexes of the type M(nih)(L)](PF6)(n)center dot xAH(2)O and M(nih)(2)](PF6)center dot xH(2)O (where M = Co(III) or Ni(II), L = 1,10-phenanthroline (phen)/or 2,2' bipyridine (bpy), nih = 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone, n = 2 or 1 and x = 3 or 2) have been synthesized and characterized by elemental analysis, magnetic, IR and H-1 NMR spectral data. The electronic and magnetic moment 2.97-3.07 B.M. data infers octahedral geometry for all the complexes. The IR data reveals that Schiff base (nih) form coordination bond with the metal ion through azomethine-nitrogen, phenolic-oxygen and carbonyl-oxygen in a tridentate fashion. In addition, DNA-binding properties of these six metal complexes were investigated using absorption spectroscopy, viscosity measurements and thermal denaturation methods. The results indicated that the nickel(II) complex strongly bind with calf-thymus DNA with intrinsic DNA binding constant K-b value of 4.9 x 10(4) M-1 for (3), 4.2 x 10(4) M-1 for (4), presumably via an intercalation mechanism compared to cobalt(III) complex with K-b value of 4.6 x 10(4) M-1 (1) and 4.1 x 10(4) M-1 (2). The DNA Photoclevage experiment shows that, the complexes act as effective DNA cleavage agent. (C) 2012 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Publication:	Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Mixed Ligand Metal Complexes; DNA Binding; DNA Photocleavage; Antimicrobial-Activity
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	27 May 2013 11:04
Last Modified:	27 May 2013 11:04
URI:	http://eprints.iisc.ac.in/id/eprint/46582

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