Surface modification and paclitaxel drug delivery of folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles

Venkatasubbu, Devanand G and Ramasamy, S and Avadhani, GS and Ramakrishnan, V and Kumar, J (2013) Surface modification and paclitaxel drug delivery of folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles. In: POWDER TECHNOLOGY, 235 . pp. 437-442.

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Abstract

Nanoparticles are used for a number of biomedical applications. In this work we report the synthesis of folic acid (FA) modified polyethylene glycol (PEG) functionalized hydroxyapatite (HAp) nanoparticles. The anticancer drug, paclitaxel, is attached to the folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles and the in vitro drug release is analyzed. The surface modification and functionalization is confirmed by Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA) and UV spectroscopy. The importance of the paper is the investigation of the release behavior of paclitaxel conjugated folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles. The results show an initial rapid release and then a sustained release. (C) 2012 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Publication:	POWDER TECHNOLOGY
Publisher:	ELSEVIER SCIENCE SA
Additional Information:	Copyright for this article belongs to the ELSEVIER SCIENCE SA, SWITZERLAND.
Keywords:	Hydroxyapatite nanoparticles; PEG; Folic acid; Drug targeting; Paclitaxel
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	29 Apr 2013 11:52
Last Modified:	29 Apr 2013 11:52
URI:	http://eprints.iisc.ac.in/id/eprint/46469

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