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Mixed-ligand nickel(II) thiosemicarbazone complexes: Synthesis, characterization and biological evaluation

Saswati, * and Dinda, Rupam and Schmiesing, Carla S and Sinn, Ekkehard and Patil, Yogesh P and Nethaji, M and Stoeckli-Evans, Helen and Acharyya, Rama (2013) Mixed-ligand nickel(II) thiosemicarbazone complexes: Synthesis, characterization and biological evaluation. In: POLYHEDRON, 50 (1). pp. 354-363.

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Official URL: http://dx.doi.org/10.1016/j.poly.2012.11.031


The syntheses and characterization of some new mixed-ligand nickel(II) complexes {Ni(L-1)(PPh3)] (1), Ni(L-1)(Py)] (2), Ni(L-2)(PPh3)]center dot DMSO (3), Ni(L-2)(Imz)] (4), Ni(L-3)(4-pic)] (5) and RNi(L-3))(2)(mu-4,4'-byp)]center dot 2DMSO (6)1 of three selected thiosemicarbazones the 4-(p-X-phenyl)thiosemicarbazones of salicylaldehyde) (H2L1-3) (A, Scheme 1) are described in the present study, differing in the inductive effect of the substituent X (X = F, Br and OCH3), in order to observe its influence, if any, on the redox potentials and biological activity of the complexes. All the synthesized ligands and the metal complexes were successfully characterized by elemental analysis, IR, UV-Vis, NMR spectroscopy and cyclic voltammetry. The molecular structures of four mononuclear (1-3 and 5) and one dinuclear (6) Ni(II) complex have been determined by X-ray crystallography. The complexes have been screened for their antibacterial activity against Escherichia coli and Bacillus. The minimum inhibitory concentrations of these complexes and their antibacterial activities indicate that compound 4 is the potential lead molecule for drug designing. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Publication: POLYHEDRON
Additional Information: Copyright for this article belongs to the PERGAMON-ELSEVIER SCIENCE LTD, ENGLAND.
Keywords: Thiosemicarbazone; Nickel(II) complexes; X-ray crystal structure; Antibacterial study
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 15 Apr 2013 11:50
Last Modified: 15 Apr 2013 11:50
URI: http://eprints.iisc.ac.in/id/eprint/46398

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