Synthesis, crystal structure, DNA binding and cleavage activities of oximato bridged cationic dinuclear copper(II) complex having labile ligands

Haribabu, P and Reddy, Hussain K and Patil, Yogesh P and Nethaji, M (2013) Synthesis, crystal structure, DNA binding and cleavage activities of oximato bridged cationic dinuclear copper(II) complex having labile ligands. In: INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 52 (3). pp. 327-333.

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Abstract

Oximato bridged dinuclear copper(II) complex Cu(L)(CH3OH)](2)(ClO4)(2) with an oxime-Schiff base ligand, viz. 3-2-(dimethylamino)ethyl]imino]-2-butanoneoxime (HL), has been synthesized and structurally characterized. The dinuclear copper(II) complex crystallizes in monoclinic space group P2(1)/n with the unit cell parameters, a = 13.3564(9) angstrom, b = 12.0821(8) angstrom, c = 17.5045(11) angstrom, beta = 90.097, V = 2824.8(3) angstrom(3), Z = 4, R = 0.0769. The complex shows quasi-reversible cyclic voltammetric response at 0.844V (Delta E-p = 276 mV) at 100 mVs(-1). The binding studies of the complex with calf thymus DNA has been investigated using absorption spectrophotometry. Cleavage activity of the complex has been carried out on double stranded pBR 322 plasmid DNA by using gel electrophoresis experiments in the absence and in the presence of the oxidant, viz., H2O2.

Item Type:	Journal Article
Publication:	INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY
Publisher:	NATL INST SCIENCE COMMUNICATION-NISCAIR
Additional Information:	Copyright for this article belongs to the NATL INST SCIENCE COMMUNICATION-NISCAIR, INDIA.
Keywords:	Coordination chemistry; Bioinorganic chemistry; Schiff bases; Oxime-Schiff base ligands; Oximato bridged complexes; Dinuclear complexes; X-ray crystallography; DNA binding; DNA cleavage activity; Copper
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	17 Apr 2013 11:54
Last Modified:	17 Apr 2013 11:54
URI:	http://eprints.iisc.ac.in/id/eprint/46392

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