Non-neutral evolution in non-LEE-encoded type III effectors of attaching and effacing Escherichia coli

Eswarappa, Sandeepa M and Janice, Jessin and Balasundaram, Sudhagar V and Chakravortty, Dipshikha (2013) Non-neutral evolution in non-LEE-encoded type III effectors of attaching and effacing Escherichia coli. In: MICROBES AND INFECTION, 15 (2). pp. 147-151.

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Abstract

Attaching and effacing Escherichia coli (AEEC) employ type III secretion system (T3SS) to secrete effector proteins into host cells and regulate their function. Here we have investigated T3SS genes of AEEC for non-neutral evolution. Our analysis revealed non-neutral evolution in three genes (nleE1, nleB2 and nleD) which encode effector proteins. These genes are located outside the locus of enterocyte effacement (LEE). In general, non-LEE effector genes show greater deviation from neutral evolution than LEE effector genes. These results suggest that effector genes located outside LEE are under greater selection pressure than those present in LEE. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Item Type:	Journal Article
Publication:	MICROBES AND INFECTION
Publisher:	ELSEVIER SCIENCE BV
Additional Information:	Copyright for this article belongs to ELSEVIER SCIENCE BV, NETHERLANDS.
Keywords:	Type 3 secretion system;Non-neutral evolution;E. coli;Non-LEE-encoded effectors
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	18 Mar 2013 05:27
Last Modified:	18 Mar 2013 05:27
URI:	http://eprints.iisc.ac.in/id/eprint/46076

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