Biocides - resistance, cross-resistance mechanisms and assessment

Gnanadhas, Divya Prakash and Marathe, Sandhya Amol and Chakravortty, Dipshikha (2013) Biocides - resistance, cross-resistance mechanisms and assessment. In: EXPERT OPINION ON INVESTIGATIONAL DRUGS, 22 (2). pp. 191-206.

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Abstract

Importance of the field: Antibiotic resistance in bacterial pathogens has increased worldwide leading to treatment failures. Concerns have been raised about the use of biocides as a contributing factor to the risk of antimicrobial resistance (AMR) development. In vitro studies demonstrating increase in resistance have often been cited as evidence for increased risks. It is therefore important to understand the mechanisms of resistance employed by bacteria toward biocides used in consumer products and their potential to impart cross-resistance to therapeutic antibiotics. Areas covered: In this review, the mechanisms of resistance and cross-resistance reported in the literature toward biocides commonly used in consumer products are summarized. The physiological and molecular techniques used in describing and examining these mechanisms are reviewed and application of these techniques for systematic assessment of biocides for their potential to develop resistance and/or cross-resistance is discussed. Expert opinion: The guidelines in the usage of biocides in household or industrial purpose should be monitored and regulated to avoid the emergence of any MDR strains. The genetic and molecular methods to monitor the resistance development to biocides should be developed and included in preclinical and clinical studies.

Item Type:	Journal Article
Publication:	EXPERT OPINION ON INVESTIGATIONAL DRUGS
Publisher:	INFORMA HEALTHCARE
Additional Information:	Copyright for this article belongs to INFORMA HEALTHCARE, ENGLAND
Keywords:	biguanides;biocide resistance;biocides;cross-resistance;disinfectant;quaternary ammonium compound;resistance detection
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	18 Feb 2013 09:06
Last Modified:	18 Feb 2013 10:57
URI:	http://eprints.iisc.ac.in/id/eprint/45812

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